Before the Natchez, other indigenous cultures had occupied this strategic area for thousands of years. The Natchez spoke a language isolate not related to the Muskogean languages of the other major tribes in the area. The area that is now Vicksburg was long occupied by the Natchez Native Americans as part of their historical territory along the Mississippi. The city is home to three large installations of the United States Army Corps of Engineers, which has often been involved in local flood control. Vicksburg's population is majority African American. After the war came Reconstruction and then a violent return to power by white supremacists and the Democrat Party in 18, including the Vicksburg massacre. Grant, along with the concurrent Battle of Gettysburg, marked the turning-point of the war. During the American Civil War, it was a key Confederate river-port, and its July 1863 surrender to Ulysses S. They conducted fur trading with the Natchez and others, and started plantations. The first Europeans who settled the area were French colonists who built Fort Saint Pierre in 1719 on the high bluffs overlooking the Yazoo River at present-day Redwood.

It was incorporated as Vicksburg in 1825 after Methodist missionary Newitt Vick. The outpost withstood an attack from the native Natchez people. Located on a high bluff on the east bank of the Mississippi River across from Louisiana, Vicksburg was built by French colonists in 1719.

It is the county seat and has a population as of 2020 of 21,573. Vicksburg is a historic city in Warren County, Mississippi, United States.

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